Teskey GC, Valentine PA
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
22: (2) 195-207 MAR 1998

Abstract

The search for the cellular processes that underlie information storage within neuronal systems lead to the development of two models of post-activation potentiation, long-term potentiation (LTP) and kindling. Both models give rise to a long-lasting increase in synaptic strength and altered unit discharge patterns. The present paper reviews synaptic plasticity in the neocortex of awake freely moving rats following both single and multiple sessions of activation with high-frequency, tetanic electrical stimulation. The phenomenology of neocortical post-activation potentiation and some possible underlying mechanisms are discussed. We speculate that the functional significance of potentiated responses may reflect a reorganization of the neocortex in a manner similar to those that create and define receptive fields.

Author Keywords

long-term potentiation, LTP, long-term depression, LTD, kindling, plasticity, memory, neocortex, isocortex, behaviour, corpus callosum, posterior hypothalamus, modulatory, neurotransmitters, receptive field

KeyWords Plus

LONG-TERM POTENTIATION, KINDLING-INDUCED POTENTIATION, RABBIT FOLLOWING STIMULATION, PRIMARY AUDITORY-CORTEX, D-ASPARTATE RECEPTORS, VISUAL-CORTEX, SYNAPTIC TRANSMISSION, PERFORANT PATH, PYRIFORM CORTEX, DENTATE GYRUS

Addresses

Teskey GC, Univ Calgary, Dept Psychol, Behav Neurosci Res Grp, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
Univ Calgary, Dept Psychol, Behav Neurosci Res Grp, Calgary, AB T2N 1N4, Canada.

Publisher

PERGAMON-ELSEVIER SCIENCE LTD, OXFORD

IDS Number

ZJ877

ISSN

0149-7634