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Richard Dyck

  • Professor
  • +1 (403) 220-4206
  • +1 (403) 220-5093

Interests

Our mission is to uncover behavioural, cellular and synaptic mechanisms that are responsible for mediating experience- and activity-dependent changes to the neural circuitry of the cerebral cortex. We are interested in understanding changes that occur normally, in the developing and adult cortex, as well as when things go awry. We apply multidisciplinary approaches, including molecular, genetic, anatomical, and behavioural assays in a model nervous system - the mouse's - to reveal mechanisms of plasticity in the cerebral cortex.

Research Support

Canadian Institutes of Health Research
Natural Sciences and Engineering Research Council of Canada

Recent Publications

McAllister BB, Dyck RH (2017) A new role for zinc in the brain, eLife 2017; 6:e31816  DOI: 10.7554/eLife.31816

Wu H-P, Dyck RH (in press) Signaling by synaptic zinc is required for whisker-mediated, fine texture discrimination, Neuroscience. 

Kiryanova V, Smith VM, Antle MC, Dyck RH (in press) Behaviour of adult 5-HT1a receptor knockout mice exposed to stress during development, Neuroscience.

Kiryanova V, Meunier SJ, Dyck RH (2017) Behavioural outcomes of female offspring following maternal stress and perinatal fluoxetine exposure, Behavioural Brain Research, 331:84-91.

McAllister BB, Dyck RH (2017) Zinc transporter 3 (ZnT3) and vesicular zinc in central nervous system function, Neuroscience & Biobehavioral Reviews, 80:329-350.

Thackray SE, McAllister BB, Dyck RH (2017) Behavioral characterization of female zinc transporter 3 (ZnT3) knockout mice, Behavioural Brain Research, 321:36-49.

Dennis DJ, Wilkinson G, Li S, Dixit R, Adnani L, Balakrishnan A, Han S, Kovach C, Gruenig N, Kurrasch DM, Dyck RH, Schuurmans C (2017) Neurog2 and Ascl1 together regulate a postmitotic derepression circuit to govern laminar fate specification in the murine neocortex. Proceedings of the National Academy of Sciences, 114(25): E4934-E4943.

Kiryanova V, Smith V, Dyck RH, Antle MA (2017) Circadian behavior of adult mice exposed to stress and fluoxetine during development. Psychopharmacology, 234(5): 793-804. 

Kiryanova V, Meunier SJ, Vecchiarelli H, Hill MN, Dyck RH (2016) The effects of stress and perinatal fluoxetine exposure on behavioural outcomes of adult male offspring. Neuroscience, 320:281-296.

Bemister TB, Brooks B, Dyck RH, Kirton A (2015) Predictors of maternal depression and family functioning after perinatal stroke. BMC Pediatrics, 15(75):1-11.DOI 10.1186/s12887-015-0397-5

Macphail E, Dyck R (2015) Correlations amongst mental health, cognitive flexibility, and zinc status, Journal of Undergraduate Research in Alberta, 4:7.

McAllister BB, Spanswick SC, Patel PP, Barneto AA, Dyck RH (2015) The effects of chronic fluoxetine treatment following injury of medial frontal cortex in mice, Behavioral Brain Research, 290:102-118.

Rosin JM, McAllister BB, Dyck RH, Percival CJ, Kurrasch DM, Cobb JA (2015) Mice lacking the transcription factor SHOX2 display impaired cerebellar development and deficits in motor coordination. Developmental Biology, 399(1):54-67.

Smith VM, Jeffers RT, McAllister BB, Basu P, Dyck RH, Antle MC (2015) Effects of lighting condition on circadian behaviour in 5-HT1A receptor knockout mice. Physiology & Behavior, 139:136-144.

Bemister TB, Brooks B, Dyck RH, Kirton A (2014) Parent and family impact of raising a child with perinatal stroke. BMC Pediatrics,14(182):1-11. DOI:101186/1471-2431-14-182.

Kiryanova V, Dyck RH (2014) Increased aggression, improved spatial memory, and reduced anxiety-like behaviour in adult male mice exposed to fluoxetine early in life. Developmental Neuroscience, 36(5):396-408.

Rakai B, Chrusch M, Spanswick SC, Dyck RH, Antle MC (2014) Survival of adult generated hippocampal neurons is altered in circadian arrhythmic mice. PLoS One, 9(6) e99527.

Kiryanova V*, McAllister BB*, Dyck RH (2013) Long-term outcomes of developmental exposure to fluoxetine: A review of the animal literature. Developmental Neuroscience, 35:437-449. *co-first authors.

Mak GK, Antle MC, Dyck RH, Weiss S (2013) Bi-parental care contributes to sexually dimorphic neural cell genesis in the adult mammalian brain. PLOS One, 8(5):e62701 16 pp.

Wu H-P, Ioffe J, Iverson MM, Boon JM, Dyck RH (2013) Novel, whisker-dependent texture discrimination task for mice. Behavioral Brain Research, 237:238-242.

Kiryanova V, Smith VM, Dyck RH, Antle MC (2013) The effects of perinatal fluoxetine treatment on the circadian system of the adult mouse. Psychopharmacology, 225:743-751. 

McAllister BB, Kiryanova V, Dyck RH (2012) Behavioural outcomes of perinatal maternal fluoxetine treatment. Neuroscience 226:356-366.

Spanswick S, Dyck RH (2012) Object/context specific memory deficits following medial frontal cortex damage in mice. PLoS ONE, 7:1-7.

Degrees

Students

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