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Circadian behaviour of adult mice exposed to stress and fluoxetine during development

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Kiryanova V, Smith V, Dyck RH, Antle MA (2016) Circadian behavior of adult mice exposed to stress and fluoxetine during development. Psychopharmacology, doi:10.1007/s00213-016-4515-3.


Women of child-bearing age are the population at greatest risk for depression. The stress experienced during pregnancy and the associated antidepressant treatments can both affect fetal development. Fluoxetine (FLX) is among the most common antidepressants used by pregnant women. We have previously demonstrated that perinatal exposure to FLX can alter expression of circadian rhythms in adulthood. Here, we examine the combined effects of maternal stress during pregnancy and perinatal exposure to the antidepressant FLX on the circadian behavior of mice as adults.

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